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1 article(s) from Simpson, Edward L.

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD⁺ analogues

Sarah Wallrodt,
Edward L. Simpson and
Andreas Marx

Beilstein J. Org. Chem. 2017, 13, 495–501, doi:10.3762/bjoc.13.49

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Graphical Abstract

Figure 1: NAD⁺ is used as a substrate by ARTDs to form MARylated and PARylated proteins. Depicted are alkyne-...

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Figure 2: Workflow of the ADP-ribosylation assay. The protein of interest (POI) is ADP-ribosylated by the res...

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Figure 3: SDS PAGE analysis of ADP-ribosylation of histone H1.2 with ARTD1, ARTD2, ARTD5 and ARTD6 using NAD⁺...

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Figure 4: SDS PAGE analysis of ADP-ribosylation of histone H1.2 with ARTD2, ARTD5 and ARTD 6 using NAD⁺ analo...

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Published 10 Mar 2017

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Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD+ analogues

Investigation of the action of poly(ADP-ribose)-synthesising enzymes on NAD⁺ analogues